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The common disadvantage of soluble powders is that they pose an inhalation risk. When handling soluble powders, there is a potential for particles to become airborne, making them easy to inhale. This poses a health risk not only to those applying the pesticide but also to others in the vicinity. Protective measures, such as wearing respirators and ensuring adequate ventilation, are often required to mitigate this risk. Addressing inhalation hazards is crucial in maintaining safety standards and protecting workers from respiratory issues.

In contrast, while certain soluble powders may require specific storage conditions to maintain their efficacy, or have increased risks of phytotoxicity (damage to plants), these factors do not represent the predominant risk compared to the inhalation potential. Additionally, the mixing procedures for soluble powders are generally straightforward, as they dissolve in water without the need for complicated preparation methods.